P-Type Voltage-Gated Calcium Channel (VGCC) Autoantibody - RIA

The RSR Voltage-Gated Calcium Channel autoantibody radioimmunoassay (VGCC Ab RIA) kit is intended for use by professional persons only, for the quantitative determination of P-type VGCC autoantibodies (VGCC Ab) in human serum.

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease, often associated with small cell lung cancer, in which autoantibodies are directed against voltage-gated calcium channels (VGCCs). The VGCCs can be classified by their electrophysiological characteristics into at least 4 subtypes (T, L, N and P).

In the case of LEMS, autoantibodies to P-type VGCCs are most important and the RSR’s kit provides a specific and sensitive assay for VGCC Ab.